Senior year at all-girl's Catholic school St. Joan's Academy has just begun, and Colleen Rowley and her friends are feeling the heat. Applications to Harvard, the battle for valedictorian, the high expectations of their parents, meeting boys in Cambridge, all of it has turned school into a pressure cooker. When girls start experiencing strange tics and other mysterious symptoms at Colleen's high school, her small town of Danvers, Massachusetts, falls victim to rumors that lead to full-blown panic, and only Colleen connects their fate to the ill-fated Salem Village, where another group of girls suffered from a similarly bizarre epidemic three centuries ago.